Uniwersytet Wrocławski - Wydział Chemii

Informacje osobiste
Stopień/tytuł
dr inż.
Imię i nazwisko
Alicja Kluczyk
Stanowisko

adiunkt

Telefon
+48 71 375 7218
Pokój
239 (budynek B)
User profile picture
Kariera naukowa
Mgr 1991, Dr 1998
Konsultacje

Rok akademicki 2016/17, semestr letni

Wtorek, 13:00 - 15:00
Konsultacje odbywają się w pokoju 241B.

Konsultacje w razie potrzeb mogą odbyć się w innym terminie.

Lista publikacji
Wersja do druku

Sumaryczny impact factor: 127.611

Liczba publikacji: 54

1. Adamska-Bartłomiejczyk Anna, Janecka Anna, Szabó Márton Richárd, Cerlesi Maria Camilla, Calo Girolamo, Kluczyk Alicja, Tömböly Csaba, Borics Attila
Cyclic mu-opioid receptor ligands containing multiple N-methylated amino acid residues.
Bioorganic & Medicinal Chemistry Letters, 2017, 27, 1644-1648.
IF: 2.454
10.1016/j.bmcl.2017.03.016

2. Adamska-Bartłomiejczyk Anna, De Marco Rossella, Gentilucci Luca, Kluczyk Alicja, Janecka Anna
Design and characterization of opioid ligands based on cycle-in-macrocycle scaffold.
Bioorganic & Medicinal Chemistry, 2017, 25, 2399-2405.
IF: 2.93
10.1016/j.bmc.2017.02.057

3. Gach-Janczak Katarzyna, Piekielna-Ciesielska Justyna, Adamska-Bartłomiejczyk Anna, Perlikowska Renata, Kruszyński Rafał, Kluczyk Alicja, Krzywik Julia, Sukiennik Jarosław, Cerlesi Maria Camilla, Calo Girolamo, Wasilewski Andrzej, Zielińska Marta, Janecka Anna
Synthesis and activity of opioid peptidomimetics with β2- and β3-amino acids.
Peptides, 2017, 95, 116-123.
IF: 2.535
10.1016/j.peptides.2017.07.015

4. Setner Bartosz, Rudowska Magdalena, Kluczyk Alicja, Stefanowicz Piotr, Szewczuk Zbigniew
The 5-azoniaspiro[4.4]nonyl group for improved MS peptide analysis : a novel non-fragmenting ionization tag for mass spectrometric sensitive sequencing of peptides.
Analytica Chimica Acta, 2017, 986, 71-81.
IF: 4.95
10.1016/j.aca.2017.07.029

5. Biernat Monika, Cydzik Marzena M., Stefanowicz Piotr, Kluczyk Alicja, Artym Jolanta, Zimecki Michał, Szewczuk Zbigniew
Cyclodimerization of immunosuppressive fragment of HLA-DR molecule : design, synthesis and ESI-MS/MS analysis.
Journal of Peptide Science, 2016, 22, 525-532.
IF: 1.972
10.1002/psc.2898

6. Jankowski Andrzej, Jankowski Adam, Kluczyk Alicja, Szemik-Hojniak Anna
Effect of neutral salts on the excited state proton transfer in the fluorescent probe anchored to the uncharged micelles.
Journal of Photochemistry and Photobiology A-Chemistry, 2016, 329, 203-212.
IF: 2.625
10.1016/j.jphotochem.2016.06.028

7. Adamska Anna, Kluczyk Alicja, Cerlesi Maria Camilla, Calo Girolamo, Janecka Anna, Borics Attila
Synthesis biological evaluation and structural analysis of novel peripherally active morphiceptin analogs.
Bioorganic & Medicinal Chemistry, 2016, 24, 1582-1588.
IF: 2.93
10.1016/j.bmc.2016.02.034

8. Perlikowska Renata, Piekielna Justyna, Gentilucci Luca, De Marco Rossella, Cerlesi Maria Camilla, Calo Girolamo, Artali R., Tömböly Csaba, Kluczyk Alicja, Janecka Anna
Synthesis of mixed MOR/KOR efficacy cyclic opioid peptide analogs with antinociceptive activity after systemic administration.
European Journal of Medicinal Chemistry, 2016, 109, 276-286.
IF: 4.519
10.1016/j.ejmech.2015.12.012

9. Kielmas Martyna, Kijewska Monika, Kluczyk Alicja, Oficjalska Jolanta, Gołębiewska Bożena, Stefanowicz Piotr, Szewczuk Zbigniew
Comparison of modification sites in glycated crystallin in vitro and in vivo.
Analytical and Bioanalytical Chemistry, 2015, 407, 2557-2567.
IF: 3.125
10.1007/s00216-015-8487-7

10. Bąchor Remigiusz, Kluczyk Alicja, Stefanowicz Piotr, Szewczuk Zbigniew
Facile synthesis of deuterium-labeled denatonium cation and its application in the quantitative analysis of Bitrex by liquid chromatography-mass spectrometry.
Analytical and Bioanalytical Chemistry, 2015, 407, 6557-6561.
IF: 3.125
10.1007/s00216-015-8815-y

11. Piekielna Justyna, Kluczyk Alicja, Gentilucci Luca, Cerlesi Maria Camilla, Calo Girolamo, Tömböly Csaba, Łapiński Krzysztof, Janecki Tomasz, Janecka Anna
Ring size in cyclic endomorphin-2 analogs modulates receptor binding affinity and selectivity.
Organic and Biomolecular Chemistry, 2015, 13, 6039-6046.
IF: 3.559
10.1039/c5ob00565e

12. Bąchor Remigiusz, Kluczyk Alicja, Stefanowicz Piotr, Szewczuk Zbigniew
Synthesis and mass spectrometry analysis of quaternary cryptando-peptidic conjugates.
Journal of Peptide Science, 2015, 21, 879-886.
IF: 1.951
10.1002/psc.2830

13. Adamska Anna, Kolesińska Beata, Kluczyk Alicja, Kamiński Zbigniew J., Janecka Anna
Synthesis of linear and cyclic opioid-based peptide analogs containing multiple N-methylated amino acid residues.
Journal of Peptide Science, 2015, 21, 807-810.
IF: 1.951
10.1002/psc.2804

14. Piekielna Justyna, Perlikowska Renata, do-Rego Jean Claude, do-Rego Jean-Luc, Cerlesi Maria Camilla, Calo Girolamo, Kluczyk Alicja, Łapiński Krzysztof, Tömböly Csaba, Janecka Anna
Synthesis of mixed opioid affinity cyclic endomorphin-2 analogues with fluorinated phenylalanines.
ACS Medicinal Chemistry Letters, 2015, 6, 579-583.
IF: 3.355
10.1021/acsmedchemlett.5b00056

15. Piekielna Justyna, Kluczyk Alicja, Perlikowska Renata, Janecka Anna
Cyclic pentapeptide analogs based on endomorphin-2 structure: Cyclization studies using liquid chromatogaraphy combined with on-line mass spectrometry and tandem mass spectrometry.
Peptides, 2014, 55, 32-40.
IF: 2.618
10.1016/j.peptides.2014.02.001

16. Bąchor Remigiusz, Rudowska Magdalena, Kluczyk Alicja, Stefanowicz Piotr, Szewczuk Zbigniew
Hydrogen-deuterium exchange of α-carbon protons and fragmentation pathways in N-methylated glycine and alanine-containing peptides derivatized by quaternary ammonium salts.
Journal of Mass Spectrometry, 2014, 49, 529-536.
IF: 2.379
10.1002/jms.3371

17. Modzel Maciej, Płóciennik Halina, Kluczyk Alicja, Stefanowicz Piotr, Szewczuk Zbigniew
Microwave-assisted 18O labeling of Fmoc-protected amino acids.
Journal of Peptide Science, 2014, 20, 896-900.
IF: 1.546
10.1002/psc.2682

18. Perlikowska Renata, Malfacini Davide, Cerlesi Maria Camilla, Calo Girolamo, Piekielna Justyna, Floriot Léonore, Henry Tiphaine, do-Rego Jean Claude, Tömböly Csaba, Kluczyk Alicja, Janecka Anna
Pharmacological characterization of endomorphin-2-based cyclic pentapeptides with methylated phenylalanine residues.
Peptides, 2014, 55, 145-150.
IF: 2.618
10.1016/j.peptides.2014.03.001

19. Kijewska Monika, Kuc Adam, Kluczyk Alicja, Waliczek Mateusz, Man-Kupisinska Aleksandra, Łukasiewicz Jolanta, Stefanowicz Piotr, Szewczuk Zbigniew
Selective detection of carbohydrates and their peptide conjugates by ESI-MS using synthetic quaternary ammonium salt derivatives of phenylboronic acids.
Journal of the American Society for Mass Spectrometry, 2014, 25, 966-976.
IF: 2.945
10.1007/s13361-014-0857-4

20. Bąchor Remigiusz, Setner Bartosz, Kluczyk Alicja, Stefanowicz Piotr, Szewczuk Zbigniew
The unusual hydrogen-deuterium exchange of α-carbon protons inN-substituted glycine-containing peptides.
Journal of Mass Spectrometry, 2014, 49, 43-49.
IF: 2.379
10.1002/jms.3318

21. Rudowska Magdalena, Wieczorek Robert, Kluczyk Alicja, Stefanowicz Piotr, Szewczuk Zbigniew
Gas-phase fragmentation of oligoproline peptide ions lacking easily mobilizable protons.
Journal of the American Society for Mass Spectrometry, 2013, 24, 846-856.
IF: 3.193
10.1007/s13361-013-0585-1

22. Wojewska Dominika, Kluczyk Alicja, Ślepokura Katarzyna
Geometric changes around an N atom due to a urethane-type bis(tert-butoxycarbonyl) substituent.
Acta Crystallographica Section C: Crystal Structure Communications, 2013, C69, 82-86.
IF: 0.535
10.1107/S0108270112048846

23. Bąchor Remigiusz, Kluczyk Alicja, Stefanowicz Piotr, Szewczuk Zbigniew
New method of peptide cleavage based on Edman degradation.
Molecular Diversity, 2013, 17, 605-611.
IF: 2.544
10.1007/s11030-013-9453-y

24. Kluczyk Alicja, Cydzik Marzena M., Biernat Monika, Bąchor Remigiusz, Pasikowski Paweł, Stefanowicz Piotr, Artym Jolanta, Zimecki Michał, Szewczuk Zbigniew
Dimeric analogs of immunosuppressive decapeptide fragment of ubiquitin.
Journal of Peptide Science, 2012, 18, 456-465.
IF: 2.071

25. Bąchor Remigiusz, Cydzik Marzena, Rudowska Magdalena, Kluczyk Alicja, Stefanowicz Piotr, Szewczuk Zbigniew
Sensitive electrospray mass spectrometry analysis of one-bead-one-compound peptide libraries labeled by quaternary ammonium salts.
Molecular Diversity, 2012, 16, 613-618.
IF: 2.861

26. Rudowska Magdalena, Wojewska Dominika, Kluczyk Alicja, Bąchor Remigiusz, Stefanowicz Piotr, Szewczuk Zbigniew
The hydrogen-deuterium exchange at α-carbon atom in N, N,N,-trialkylglycine residue: ESI-MS studies.
Journal of the American Society for Mass Spectrometry, 2012, 23, 1024-1028.
IF: 3.592

27. Fichna J., Perlikowska Renata, Wyrębska A., Gach K., Piekielna Justyna, do-Rego Jean Claude, Toth G., Kluczyk Alicja, Janecki Tomasz, Janecka Anna
Effect of 2',6',-dimethyl-L-tyrosine (Dmt) on pharmacological activity of cyclic endomorphin-2 and morphiceptin analogs.
Bioorganic & Medicinal Chemistry, 2011, 19, 6977-6981.
IF: 2.921

28. Jankowski Andrzej, Wiśniewski Łukasz, Jankowski Adam, Kluczyk Alicja, Chmielewski Piotr J., Szemik-Hojniak Anna
Impact of micelle ionic electrical double layer structure on the excited state protolytic reaction in the fluorescent probe bound to the colloidal nanoparticles.
Journal of Physical Chemistry B, 2011, 115, 8078-8087.
IF: 3.696

29. Kapczyńska Katarzyna, Stefanowicz Piotr, Jaremko Łukasz, Jaremko Mariusz, Kluczyk Alicja, Szewczuk Zbigniew
The efficient synthesis of isotopically labeled peptide-derived Amadori products and their characterization.
Amino Acids, 2011, 40, 923-932.
IF: 3.248

30. Kijewska Monika, Stefanowicz Piotr, Kluczyk Alicja, Szewczuk Zbigniew
The isotopic exchange of oxygen as a tool for detection of the glycation sites in proteins.
Analytical Biochemistry, 2011, 419, 81-87.
IF: 2.996

31. Stefanowicz Piotr, Kijewska Monika, Kluczyk Alicja, Szewczuk Zbigniew
Detection of glycation sites in proteins by high-resolution mass spectrometry combined with isotopic labeling.
Analytical Biochemistry, 2010, 400, 237-243.
IF: 3.236

32. Kluczyk Alicja, Rudowska Magdalena, Stefanowicz Piotr, Szewczuk Zbigniew
Microwave-assisted TFA cleavage of peptides from Merrifield resin.
Journal of Peptide Science, 2010, 16, 31-39.
IF: 1.954

33. Kijewska Monika, Kluczyk Alicja, Stefanowicz Piotr, Szewczuk Zbigniew
Electrospray ionization mass spectrometric analysis of complexes between peptide-derived Amadori products and borate ions.
Rapid Communications in Mass Spectrometry, 2009, 23, 4038-4046.
IF: 2.695

34. Skarlas T., Panou-Pomonis E., Kluczyk Alicja, Szewczuk Zbigniew, Zimecki Michał, Kosmopoulou A., Sakarellos-Daitsiotis M., Sakarellos C.
HLA-DQ7β1 and β2 derived peptides as immunomodulators.
Journal of Peptide Science, 2009, 15, 296-304.
IF: 1.807

35. Koprowska-Ratajska Małgorzata, Kluczyk Alicja, Stefanowicz Piotr, Bartosz-Bechowski Hubert, Szewczuk Zbigniew
Solid phase synthesis of peptides containing novel amino acids, substituted 3-benzimidazolealanines.
Amino Acids, 2009, 36, 309-315.
IF: 3.877

36. Stefanowicz Piotr, Kapczyńska Katarzyna, Kluczyk Alicja, Szewczuk Zbigniew
A new procedure for the synthesis of peptide-derived Amadori products on a solid support.
Tetrahedron Letters, 2007, 48, 967-969.
IF: 2.615

37. Kluczyk Alicja, Kiyota T., Lazar C., Popek Tomasz, Roman G., Konishi Y.
Drug evolution concept in drug design: 2. Chimera method.
Medicinal Chemistry, 2006, 2, 175-189.
IF: 0

38. Kluczyk Alicja, Szefczyk B., Amrhein N., Zoń Jerzy
(E)-cinnamic acid analogues as inhibitors of phenylalanine ammonia-lyase and of anthocyanin biosynthesis.
Polish Journal of Chemistry, 2005, 79, 583-592.
IF: 0.513

39. Siemion Ignacy Z., Kluczyk Alicja, Cebrat Marek
The peptide molecular links between the central nervous and the immune systems.
Amino Acids, 2005, 29, 161-176.
IF: 2.172

40. Lazar C., Kluczyk Alicja, Kiyota T., Konishi Y.
Drug evolution concept in drug design: 1. Hybridization method.
Journal of Medicinal Chemistry, 2004, 47, 6973-6982.
IF: 5.076

41. Kluczyk Alicja, Cebrat Marek, Zbozień-Pacamaj Renata, Lisowski Marek, Stefanowicz Piotr, Wieczorek Zbigniew, Siemion Ignacy Z.
On the peptide-antipeptide interactions in interleukin-1 receptor system.
Acta Biochimica Polonica, 2004, 51, 57-66.
IF: 1.032

42. Siemion Ignacy Z., Cebrat Marek, Kluczyk Alicja
The problem of amino acid complementarity and antisense peptides.
Current Protein and Peptide Science, 2004, 5, 507-527.
IF: 3

43. Kluczyk Alicja, Popek Tomasz, Kiyota T., de Macedo P., Stefanowicz Piotr, Lazar C., Konishi Y.
Drug evolution: p-aminobenzoic acid as a building block.
Current Medicinal Chemistry, 2002, 9, 1871-1892.
IF: 4.966

44. Kluczyk Alicja, Siemion Ignacy Z., Szewczuk Zbigniew, Wieczorek Zbigniew
The immunosuppressive activity of peptide fragments of vaccinia virus C10L protein and a hypothesis on the role of this protein in the viral invasion.
Peptides, 2002, 23, 823-834.
IF: 2.635

45. Kluczyk Alicja, Siemion Ignacy Z., Wieczorek Zbigniew
The "two-headed" peptide inhibitors of interleukin-1 action.
Peptides, 2000, 21, 1411-1420.
IF: 1.867

46. Siemion Ignacy Z., Kluczyk Alicja
Tuftsin: On the 30-year anniversary of Victor Najjar's discovery,.
Peptides, 1999, 20, 645-674.
IF: 2.173

47. Siemion Ignacy Z., Kluczyk Alicja, Wieczorek Zbigniew
Anti-IL-1 activity of peptide fragments of IL-1 family proteins.
Peptides, 1998, 19, 373-382.
IF: 2.038

48. Wieczorek Zbigniew, Kluczyk Alicja, Słoń Jacek J., Siemion Ignacy Z.
A hexapeptide VTKFYF from C-terminal part of interleukin-1 receptor antagonist, an inhibitor of IL- 1-IL-1 receptor interaction.
Polish Journal of Pharmacology, 1997, 49, 107-117.
IF: 0

49. Kluczyk Alicja, Siemion Ignacy Z., Słoń Jacek J., Wieczorek Zbigniew
Immunomodulatory activity of oligopeptides related to interleukin 1 receptor antagonist sequence.
Archivum Immunologiae et Therapiae Experimentalis, 1997, 45, 427-433.
IF: 0

50. Siemion Ignacy Z., Szewczuk Zbigniew, Kluczyk Alicja, Słoń Jacek J., Wieczorek Zbigniew
On the "immunostimulative" and "immunosuppressive" conformation of thymopentin analogues.
Polish Journal of Chemistry, 1995, 69, 1669-1678.
IF: 0.422

51. Wieczorek Zbigniew, Słoń Jacek J., Kluczyk Alicja, Zbozień Renata, Stefanowicz Piotr, Siemion Ignacy Z.
The immunomodulatory diversity of the proteins of the transforming growth factor β (TGFβ) family.
International Journal of Peptide and Protein Research, 1995, 46, 113-118.
IF: 1.41

52. Słoń Jacek J., Kluczyk Alicja, Stefanowicz Piotr, Zimecki Michał, Wieczorek Zbigniew, Siemion Ignacy Z.
Immunological and chemical studies in the tuftsin-kentsin group.
Polish Journal of Chemistry, 1994, 68, 1043-1046.
IF: 0

53. Siemion Ignacy Z., Kluczyk Alicja, Słoń Jacek J., Zimecki Michał, Wieczorek Zbigniew
Immunosuppressive activity of analogs of tripeptide Lys-Arg-Pro with D-amino acid residues.
Archivum Immunologiae et Therapiae Experimentalis, 1994, 42, 205-207.
IF: 0

54. Siemion Ignacy Z., Stefanowicz Piotr, Kluczyk Alicja, Słoń Jacek J.
Circular dichroism of the peptides of tuftsin-kentsin group.
Polish Journal of Chemistry, 1993, 67, 2171-2180.
IF: 0