Uniwersytet Wrocławski - Wydział Chemii

Informacje osobiste
Stopień/tytuł
dr inż.
Imię i nazwisko
Alicja Kluczyk
Stanowisko

adiunkt

Telefon
+48 71 375 7218
Pokój
239 (budynek B)
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Kariera naukowa
Mgr 1991, Dr 1998
Konsultacje

Rok akademicki 2017/18, semestr letni

Czwartek, 10:30 - 12:30
Konsultacje odbywają się w pokoju 241B.

Konsultacje w razie potrzeb mogą odbyć się w innym terminie.

Lista publikacji
Wersja do druku

Sumaryczny impact factor: 132.207

Liczba publikacji: 56

1. Adamska-Bartłomiejczyk Anna, Janecka Anna, Szabó Márton Richárd, Cerlesi Maria Camilla, Calo Girolamo, Kluczyk Alicja, Tömböly Csaba, Borics Attila
Cyclic mu-opioid receptor ligands containing multiple N-methylated amino acid residues.
Bioorganic and Medicinal Chemistry Letters, 2017, 27, 1644-1648
IF: 2.454
10.1016/j.bmcl.2017.03.016

2. Adamska-Bartłomiejczyk Anna, De Marco Rossella, Gentilucci Luca, Kluczyk Alicja, Janecka Anna
Design and characterization of opioid ligands based on cycle-in-macrocycle scaffold.
Bioorganic and Medicinal Chemistry, 2017, 25, 2399-2405
IF: 2.93
10.1016/j.bmc.2017.02.057

3. Bąchor Remigiusz, Kluczyk Alicja, Stefanowicz Piotr, Szewczuk Zbigniew
Preparation of novel deuterated cyclosporin A standards for quantitative LC-MS analysis.
Journal of Mass Spectrometry, 2017, 52, 817-822
IF: 2.381
10.1002/jms.4025

4. Gach-Janczak Katarzyna, Piekielna-Ciesielska Justyna, Adamska-Bartłomiejczyk Anna, Perlikowska Renata, Kruszyński Rafał, Kluczyk Alicja, Krzywik Julia, Sukiennik Jarosław, Cerlesi Maria Camilla, Calo Girolamo, Wasilewski Andrzej, Zielińska Marta, Janecka Anna
Synthesis and activity of opioid peptidomimetics with β2- and β3-amino acids.
Peptides, 2017, 95, 116-123
IF: 2.778
10.1016/j.peptides.2017.07.015

5. Adamska-Bartłomiejczyk Anna, Borics Attila, Tömböly Csaba, Dvorácskó Szabolcs, Lisowski Marek, Kluczyk Alicja, Wołczański Grzegorz, Piekielna-Ciesielska Justyna, Janecka Anna
Synthesis, receptor binding studies, optical spectroscopic and in silico structural characterization of morphiceptin analogs with cis-4-amino-L-proline residues.
Journal of Peptide Science, 2017, 23, 864-870
IF: 1.972
10.1002/psc.3050

6. Setner Bartosz, Rudowska Magdalena, Kluczyk Alicja, Stefanowicz Piotr, Szewczuk Zbigniew
The 5-azoniaspiro[4.4]nonyl group for improved MS peptide analysis : a novel non-fragmenting ionization tag for mass spectrometric sensitive sequencing of peptides.
Analytica Chimica Acta, 2017, 986, 71-81
IF: 4.95
10.1016/j.aca.2017.07.029

7. Biernat Monika, Cydzik Marzena M., Stefanowicz Piotr, Kluczyk Alicja, Artym Jolanta, Zimecki Michał, Szewczuk Zbigniew
Cyclodimerization of immunosuppressive fragment of HLA-DR molecule : design, synthesis and ESI-MS/MS analysis.
Journal of Peptide Science, 2016, 22, 525-532
IF: 1.972
10.1002/psc.2898

8. Jankowski Andrzej, Jankowski Adam, Kluczyk Alicja, Szemik-Hojniak Anna
Effect of neutral salts on the excited state proton transfer in the fluorescent probe anchored to the uncharged micelles.
Journal of Photochemistry and Photobiology A-Chemistry, 2016, 329, 203-212
IF: 2.625
10.1016/j.jphotochem.2016.06.028

9. Perlikowska Renata, Piekielna Justyna, Gentilucci Luca, De Marco Rossella, Cerlesi Maria Camilla, Calo Girolamo, Artali R., Tömböly Csaba, Kluczyk Alicja, Janecka Anna
Synthesis of mixed MOR/KOR efficacy cyclic opioid peptide analogs with antinociceptive activity after systemic administration.
European Journal of Medicinal Chemistry, 2016, 109, 276-286
IF: 4.519
10.1016/j.ejmech.2015.12.012

10. Adamska Anna, Kluczyk Alicja, Cerlesi Maria Camilla, Calo Girolamo, Janecka Anna, Borics Attila
Synthesis, biological evaluation and structural analysis of novel peripherally active morphiceptin analogs.
Bioorganic and Medicinal Chemistry, 2016, 24, 1582-1588
IF: 2.93
10.1016/j.bmc.2016.02.034

11. Kielmas Martyna, Kijewska Monika, Kluczyk Alicja, Oficjalska Jolanta, Gołębiewska Bożena, Stefanowicz Piotr, Szewczuk Zbigniew
Comparison of modification sites in glycated crystallin in vitro and in vivo.
Analytical and Bioanalytical Chemistry, 2015, 407, 2557-2567
IF: 3.125
10.1007/s00216-015-8487-7

12. Bąchor Remigiusz, Kluczyk Alicja, Stefanowicz Piotr, Szewczuk Zbigniew
Facile synthesis of deuterium-labeled denatonium cation and its application in the quantitative analysis of Bitrex by liquid chromatography-mass spectrometry.
Analytical and Bioanalytical Chemistry, 2015, 407, 6557-6561
IF: 3.125
10.1007/s00216-015-8815-y

13. Piekielna Justyna, Kluczyk Alicja, Gentilucci Luca, Cerlesi Maria Camilla, Calo Girolamo, Tömböly Csaba, Łapiński Krzysztof, Janecki Tomasz, Janecka Anna
Ring size in cyclic endomorphin-2 analogs modulates receptor binding affinity and selectivity.
Organic and Biomolecular Chemistry, 2015, 13, 6039-6046
IF: 3.559
10.1039/c5ob00565e

14. Bąchor Remigiusz, Kluczyk Alicja, Stefanowicz Piotr, Szewczuk Zbigniew
Synthesis and mass spectrometry analysis of quaternary cryptando-peptidic conjugates.
Journal of Peptide Science, 2015, 21, 879-886
IF: 1.951
10.1002/psc.2830

15. Adamska Anna, Kolesińska Beata, Kluczyk Alicja, Kamiński Zbigniew J., Janecka Anna
Synthesis of linear and cyclic opioid-based peptide analogs containing multiple N-methylated amino acid residues.
Journal of Peptide Science, 2015, 21, 807-810
IF: 1.951
10.1002/psc.2804

16. Piekielna Justyna, Perlikowska Renata, do-Rego Jean Claude, do-Rego Jean-Luc, Cerlesi Maria Camilla, Calo Girolamo, Kluczyk Alicja, Łapiński Krzysztof, Tömböly Csaba, Janecka Anna
Synthesis of mixed opioid affinity cyclic endomorphin-2 analogues with fluorinated phenylalanines.
ACS Medicinal Chemistry Letters, 2015, 6, 579-583
IF: 3.355
10.1021/acsmedchemlett.5b00056

17. Piekielna Justyna, Kluczyk Alicja, Perlikowska Renata, Janecka Anna
Cyclic pentapeptide analogs based on endomorphin-2 structure: Cyclization studies using liquid chromatography combined with on-line mass spectrometry and tandem mass spectrometry.
Peptides, 2014, 55, 32-40
IF: 2.618
10.1016/j.peptides.2014.02.001

18. Bąchor Remigiusz, Rudowska Magdalena, Kluczyk Alicja, Stefanowicz Piotr, Szewczuk Zbigniew
Hydrogen-deuterium exchange of α-carbon protons and fragmentation pathways in N-methylated glycine and alanine-containing peptides derivatized by quaternary ammonium salts.
Journal of Mass Spectrometry, 2014, 49, 529-536
IF: 2.379
10.1002/jms.3371

19. Modzel Maciej, Płóciennik Halina, Kluczyk Alicja, Stefanowicz Piotr, Szewczuk Zbigniew
Microwave-assisted 18O labeling of Fmoc-protected amino acids.
Journal of Peptide Science, 2014, 20, 896-900
IF: 1.546
10.1002/psc.2682

20. Perlikowska Renata, Malfacini Davide, Cerlesi Maria Camilla, Calo Girolamo, Piekielna Justyna, Floriot Léonore, Henry Tiphaine, do-Rego Jean Claude, Tömböly Csaba, Kluczyk Alicja, Janecka Anna
Pharmacological characterization of endomorphin-2-based cyclic pentapeptides with methylated phenylalanine residues.
Peptides, 2014, 55, 145-150
IF: 2.618
10.1016/j.peptides.2014.03.001

21. Kijewska Monika, Kuc Adam, Kluczyk Alicja, Waliczek Mateusz, Man-Kupisinska Aleksandra, Łukasiewicz Jolanta, Stefanowicz Piotr, Szewczuk Zbigniew
Selective detection of carbohydrates and their peptide conjugates by ESI-MS using synthetic quaternary ammonium salt derivatives of phenylboronic acids.
Journal of the American Society for Mass Spectrometry, 2014, 25, 966-976
IF: 2.945
10.1007/s13361-014-0857-4

22. Bąchor Remigiusz, Setner Bartosz, Kluczyk Alicja, Stefanowicz Piotr, Szewczuk Zbigniew
The unusual hydrogen-deuterium exchange of α-carbon protons inN-substituted glycine-containing peptides.
Journal of Mass Spectrometry, 2014, 49, 43-49
IF: 2.379
10.1002/jms.3318

23. Rudowska Magdalena, Wieczorek Robert, Kluczyk Alicja, Stefanowicz Piotr, Szewczuk Zbigniew
Gas-phase fragmentation of oligoproline peptide ions lacking easily mobilizable protons.
Journal of the American Society for Mass Spectrometry, 2013, 24, 846-856
IF: 3.193
10.1007/s13361-013-0585-1

24. Wojewska Dominika, Kluczyk Alicja, Ślepokura Katarzyna
Geometric changes around an N atom due to a urethane-type bis(tert-butoxycarbonyl) substituent.
Acta Crystallographica Section C: Crystal Structure Communications, 2013, C69, 82-86
IF: 0.535
10.1107/S0108270112048846

25. Bąchor Remigiusz, Kluczyk Alicja, Stefanowicz Piotr, Szewczuk Zbigniew
New method of peptide cleavage based on Edman degradation.
Molecular Diversity, 2013, 17, 605-611
IF: 2.544
10.1007/s11030-013-9453-y

26. Kluczyk Alicja, Cydzik Marzena M., Biernat Monika, Bąchor Remigiusz, Pasikowski Paweł, Stefanowicz Piotr, Artym Jolanta, Zimecki Michał, Szewczuk Zbigniew
Dimeric analogs of immunosuppressive decapeptide fragment of ubiquitin.
Journal of Peptide Science, 2012, 18, 456-465
IF: 2.071

27. Bąchor Remigiusz, Cydzik Marzena, Rudowska Magdalena, Kluczyk Alicja, Stefanowicz Piotr, Szewczuk Zbigniew
Sensitive electrospray mass spectrometry analysis of one-bead-one-compound peptide libraries labeled by quaternary ammonium salts.
Molecular Diversity, 2012, 16, 613-618
IF: 2.861

28. Rudowska Magdalena, Wojewska Dominika, Kluczyk Alicja, Bąchor Remigiusz, Stefanowicz Piotr, Szewczuk Zbigniew
The hydrogen-deuterium exchange at α-carbon atom in N, N,N,-trialkylglycine residue: ESI-MS studies.
Journal of the American Society for Mass Spectrometry, 2012, 23, 1024-1028
IF: 3.592

29. Fichna J., Perlikowska Renata, Wyrębska A., Gach K., Piekielna Justyna, do-Rego Jean Claude, Toth G., Kluczyk Alicja, Janecki Tomasz, Janecka Anna
Effect of 2',6',-dimethyl-L-tyrosine (Dmt) on pharmacological activity of cyclic endomorphin-2 and morphiceptin analogs.
Bioorganic and Medicinal Chemistry, 2011, 19, 6977-6981
IF: 2.921

30. Jankowski Andrzej, Wiśniewski Łukasz, Jankowski Adam, Kluczyk Alicja, Chmielewski Piotr J., Szemik-Hojniak Anna
Impact of micelle ionic electrical double layer structure on the excited state protolytic reaction in the fluorescent probe bound to the colloidal nanoparticles.
Journal of Physical Chemistry B, 2011, 115, 8078-8087
IF: 3.696

31. Kapczyńska Katarzyna, Stefanowicz Piotr, Jaremko Łukasz, Jaremko Mariusz, Kluczyk Alicja, Szewczuk Zbigniew
The efficient synthesis of isotopically labeled peptide-derived Amadori products and their characterization.
Amino Acids, 2011, 40, 923-932
IF: 3.248

32. Kijewska Monika, Stefanowicz Piotr, Kluczyk Alicja, Szewczuk Zbigniew
The isotopic exchange of oxygen as a tool for detection of the glycation sites in proteins.
Analytical Biochemistry, 2011, 419, 81-87
IF: 2.996

33. Stefanowicz Piotr, Kijewska Monika, Kluczyk Alicja, Szewczuk Zbigniew
Detection of glycation sites in proteins by high-resolution mass spectrometry combined with isotopic labeling.
Analytical Biochemistry, 2010, 400, 237-243
IF: 3.236

34. Kluczyk Alicja, Rudowska Magdalena, Stefanowicz Piotr, Szewczuk Zbigniew
Microwave-assisted TFA cleavage of peptides from Merrifield resin.
Journal of Peptide Science, 2010, 16, 31-39
IF: 1.954

35. Kijewska Monika, Kluczyk Alicja, Stefanowicz Piotr, Szewczuk Zbigniew
Electrospray ionization mass spectrometric analysis of complexes between peptide-derived Amadori products and borate ions.
Rapid Communications in Mass Spectrometry, 2009, 23, 4038-4046
IF: 2.695

36. Skarlas T., Panou-Pomonis E., Kluczyk Alicja, Szewczuk Zbigniew, Zimecki Michał, Kosmopoulou A., Sakarellos-Daitsiotis M., Sakarellos C.
HLA-DQ7β1 and β2 derived peptides as immunomodulators.
Journal of Peptide Science, 2009, 15, 296-304
IF: 1.807

37. Koprowska-Ratajska Małgorzata, Kluczyk Alicja, Stefanowicz Piotr, Bartosz-Bechowski Hubert, Szewczuk Zbigniew
Solid phase synthesis of peptides containing novel amino acids, substituted 3-benzimidazolealanines.
Amino Acids, 2009, 36, 309-315
IF: 3.877

38. Stefanowicz Piotr, Kapczyńska Katarzyna, Kluczyk Alicja, Szewczuk Zbigniew
A new procedure for the synthesis of peptide-derived Amadori products on a solid support.
Tetrahedron Letters, 2007, 48, 967-969
IF: 2.615

39. Kluczyk Alicja, Kiyota T., Lazar C., Popek Tomasz, Roman G., Konishi Y.
Drug evolution concept in drug design: 2. Chimera method.
Medicinal Chemistry, 2006, 2, 175-189

40. Kluczyk Alicja, Szefczyk B., Amrhein N., Zoń Jerzy
(E)-cinnamic acid analogues as inhibitors of phenylalanine ammonia-lyase and of anthocyanin biosynthesis.
Polish Journal of Chemistry, 2005, 79, 583-592
IF: 0.513

41. Siemion Ignacy Z., Kluczyk Alicja, Cebrat Marek
The peptide molecular links between the central nervous and the immune systems.
Amino Acids, 2005, 29, 161-176
IF: 2.172

42. Lazar C., Kluczyk Alicja, Kiyota T., Konishi Y.
Drug evolution concept in drug design: 1. Hybridization method.
Journal of Medicinal Chemistry, 2004, 47, 6973-6982
IF: 5.076

43. Kluczyk Alicja, Cebrat Marek, Zbozień-Pacamaj Renata, Lisowski Marek, Stefanowicz Piotr, Wieczorek Zbigniew, Siemion Ignacy Z.
On the peptide-antipeptide interactions in interleukin-1 receptor system.
Acta Biochimica Polonica, 2004, 51, 57-66
IF: 1.032

44. Siemion Ignacy Z., Cebrat Marek, Kluczyk Alicja
The problem of amino acid complementarity and antisense peptides.
Current Protein and Peptide Science, 2004, 5, 507-527
IF: 3

45. Kluczyk Alicja, Popek Tomasz, Kiyota T., de Macedo P., Stefanowicz Piotr, Lazar C., Konishi Y.
Drug evolution: p-aminobenzoic acid as a building block.
Current Medicinal Chemistry, 2002, 9, 1871-1892
IF: 4.966

46. Kluczyk Alicja, Siemion Ignacy Z., Szewczuk Zbigniew, Wieczorek Zbigniew
The immunosuppressive activity of peptide fragments of vaccinia virus C10L protein and a hypothesis on the role of this protein in the viral invasion.
Peptides, 2002, 23, 823-834
IF: 2.635

47. Kluczyk Alicja, Siemion Ignacy Z., Wieczorek Zbigniew
The "two-headed" peptide inhibitors of interleukin-1 action.
Peptides, 2000, 21, 1411-1420
IF: 1.867

48. Siemion Ignacy Z., Kluczyk Alicja
Tuftsin: On the 30-year anniversary of Victor Najjar's discovery,.
Peptides, 1999, 20, 645-674
IF: 2.173

49. Siemion Ignacy Z., Kluczyk Alicja, Wieczorek Zbigniew
Anti-IL-1 activity of peptide fragments of IL-1 family proteins.
Peptides, 1998, 19, 373-382
IF: 2.038

50. Wieczorek Zbigniew, Kluczyk Alicja, Słoń Jacek J., Siemion Ignacy Z.
A hexapeptide VTKFYF from C-terminal part of interleukin-1 receptor antagonist, an inhibitor of IL- 1-IL-1 receptor interaction.
Polish Journal of Pharmacology, 1997, 49, 107-117

51. Kluczyk Alicja, Siemion Ignacy Z., Słoń Jacek J., Wieczorek Zbigniew
Immunomodulatory activity of oligopeptides related to interleukin 1 receptor antagonist sequence.
Archivum Immunologiae et Therapiae Experimentalis, 1997, 45, 427-433

52. Siemion Ignacy Z., Szewczuk Zbigniew, Kluczyk Alicja, Słoń Jacek J., Wieczorek Zbigniew
On the "immunostimulative" and "immunosuppressive" conformation of thymopentin analogues.
Polish Journal of Chemistry, 1995, 69, 1669-1678
IF: 0.422

53. Wieczorek Zbigniew, Słoń Jacek J., Kluczyk Alicja, Zbozień Renata, Stefanowicz Piotr, Siemion Ignacy Z.
The immunomodulatory diversity of the proteins of the transforming growth factor β (TGFβ) family.
International Journal of Peptide and Protein Research, 1995, 46, 113-118
IF: 1.41

54. Słoń Jacek J., Kluczyk Alicja, Stefanowicz Piotr, Zimecki Michał, Wieczorek Zbigniew, Siemion Ignacy Z.
Immunological and chemical studies in the tuftsin-kentsin group.
Polish Journal of Chemistry, 1994, 68, 1043-1046

55. Siemion Ignacy Z., Kluczyk Alicja, Słoń Jacek J., Zimecki Michał, Wieczorek Zbigniew
Immunosuppressive activity of analogs of tripeptide Lys-Arg-Pro with D-amino acid residues.
Archivum Immunologiae et Therapiae Experimentalis, 1994, 42, 205-207

56. Siemion Ignacy Z., Stefanowicz Piotr, Kluczyk Alicja, Słoń Jacek J.
Circular dichroism of the peptides of tuftsin-kentsin group.
Polish Journal of Chemistry, 1993, 67, 2171-2180